New EpiGrammer version: make your best Biacore™ even better

We have launched a new version of the EpiGrammer™ software that improves the performance even of top notch SPR instruments. Contact us on sales@episentum.com for a copy of our latest Application Note 26 to learn how the new version improves the signal-to-noise ratio and reduces the disturbance level of the Biacore™ T200 SPR instrument.

The new EpiGrammer 3.0 version uses improved algorithms for enhanced performance of Biacore™ T100/T200 systems. We are offering a limited number of free trial licenses to the pilot version of EpiGrammer 3.0 to selected customers. If you’re interested, please contact us on sales@episentum.com.

 

Check your SPR injections: discount offer

We are happy to offer our Validation Kit B9003 in packs of three for the price of two: €180 in Europe and $220 elsewhere (+ freight). We also include a 1-month free trial license to our EpiGrammer™ software in the package. The offer is valid throughout February 2018.

Accurate Surface Plasmon Resonance analysis requires high quality sample injection pulses. Most commercial SPR instruments offer pre-programmed “System Check” procedures that diagnose injection pulse quality in order to detect e.g. leakage, blockage, or dispersion in the microfluidic system. However, such tests are based on pure refractive index measurements, and are plagued by a number of well-known errors and artefacts.

LE-SPR offers a rigorous injection test that monitors the true transport of analyte in to and out of the detection flow cell without any refractive index artefacts. Using our LE-SPR Validation Kit, the true shape of injection pulses can be accurately assessed by simple inspection.

Learn how by checking out our Technical Note 012. Please contact us at sales@episentum.com for a copy of the TechNote.

 

Episentum presents at the NovAlix conference Biophysics in Drug Discovery, Strasbourg, France, 6-9 June 2017

Episentum will present a poster on Label-Enhanced SPR at the NovAlix conference Biophysics in Drug Discovery, Strasbourg, France, 6-9 June 2017. We will display the enhanced sensitivity in small molecule analysis, as well as the enhanced specificity and the dual-colour capabilities in protein analysis.

We’re looking forward to meeting with lots of SPR scientists and other biophysicists, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at info@episentum.com.

 

Episentum presents at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017

Episentum will present a poster at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017. The poster will demonstrate how Label-Enhanced SPR can improve the surface plasmon resonance analysis of small molecules as well as larger biomolecules.

We’re looking forward to meeting with lots of SPR users, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at info@episentum.com.

 

End-of-year offer: Free Label-Enhanced SPR software

To celebrate the approaching Holiday Season, we’re offering free licenses to our Label-Enhanced SPR software. We want to help more scientists get started with LE-SPR, and we also want to reward our existing customers. So here’s the offer:

  • Buy 1 mg of any Episentec™ dye reagent – get a free 3-month full version license to our EpiGrammer™ software.
  • Buy 2 mg of any Episentec™ dye reagents – get a free 6-month full version license to our EpiGrammer™ software.
  • And, as always, we include generous technical support on the implementation of Label-Enhanced SPR to all our customers.

For any enquiries, please contact us at sales@episentum.com.

 

Episentec evolves into Episentum

Episentec, the company that developed the pioneering Label-Enhanced SPR technology, is now evolving into Episentum. We do this change to highlight the extension of our product range.

Episentum still offers the same high-performance Episentec™ reagents and EpiGrammer™ software for Label-Enhanced SPR, and the same high level of technical support on the implementation of the technology.

We will continue developing and offering products that improve the performance of biosensor instruments, and we’re looking forward to continue serving our customers – old as well as new. For any enquiries, please contact us at sales@episentum.com.

 

End-of-year offer: Get started with Label-Enhanced SPR

To celebrate the approaching end of year 2015, we are offering the following discounts on any orders on our range of Label-Enhanced SPR products placed before the end of the year:

  • 15% discount off the list price on all Episentec™ dye reagents.
  • 25% discount off the list price on the first annual EpiGrammer™ license.
  • Free support on experimental planning and data evaluation for three months for new customers.

For any additional information, for a quotation, or to place an order, please contact sales@episentum.com.

Download pdf here:   Episentec December 2015

 

New Technical Notes published

We have published four new Technical Notes, i.e. simple guides on the practical implementation of Label-Enhanced SPR. Please check out our Technical Notes page for a complete list of available TechNotes, and please contact sales@episentum.com for a copy of any of the TechNotes.

The new TechNotes are:

Technical Note 007: A Biacore™ MDL method template for inhibition-in-solution (ISA) assays

Technical Note 008: A Biacore™ MDL method template for kinetic assays

These two TechNotes contain ready-to-use methods for customers running MDL methods on e.g. Biacore™ 2000 and Biacore™ 3000. The templates can be used right off, or modified according to the user’s requirements.

Technical Note 009: EpiGrammer™ Tutorial 1: Basic case

Technical Note 010: EpiGrammer™ Tutorial 2: Dual-colour case (two binding species)

These two TechNotes contain simple step-by-step instructions on the use of EpiGrammer™ software. TechNote 009 covers the most basic case, while TechNote 010 covers the case with two simultaneously binding species described in our Application Note 024.

 

Dual-colour SPR on a standard Biacore™ instrument

Surface Plasmon Resonance is usually regarded as an indiscriminate biosensing technique that monitors the binding of any molecule to the sensor surface, without being able to determine the identity of the binding species. However, using Label-Enhanced SPR, it is possible to discriminate and quantify the binding of two species – one dye-labelled and one unlabelled – simultaneously, even on standard single-wavelength SPR instruments. This feature is very valuable, for example, when studying complex biochemical binding mechanisms, such as competing reactions or allosteric effects. In our new Application Note 024 we present an example on a Biacore™ SPR instrument: the resolution of a mixed, two-species sensorgram into two separate sensorgrams for the two components.

For a copy of the new Application Note 024, or for any other enquiries, please contact sales@episentum.com .