Episentum will present a poster on Label-Enhanced SPR at the NovAlix conference Biophysics in Drug Discovery, Strasbourg, France, 6-9 June 2017. We will display the enhanced sensitivity in small molecule analysis, as well as the enhanced specificity and the dual-colour capabilities in protein analysis.
We’re looking forward to meeting with lots of SPR scientists and other biophysicists, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at email@example.com.
Label-Enhanced SPR (LE-SPR) can be used to clearly confirm binding site specificity. Brandon Garcia and Brian Geisbrecht at Kansas State University and their co-workers have used LE-SPR in a very elegant manner to study small-molecule inhibitors of the complement system using a standard Biacore™ T200 instrument. Taking advantage of the greatly simplified interpretation of LE-SPR data, binding site specificity was unambiguously confirmed in a way that would have been hard to achieve with conventional SPR.
The full study is recently published in The Journal of Immunology.
For more information about the LE-SPR technology, please contact us directly at firstname.lastname@example.org.
Episentum will present a poster at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017. The poster will demonstrate how Label-Enhanced SPR can improve the surface plasmon resonance analysis of small molecules as well as larger biomolecules.
We’re looking forward to meeting with lots of SPR users, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at email@example.com.
To celebrate the approaching Holiday Season, we’re offering free licenses to our Label-Enhanced SPR software. We want to help more scientists get started with LE-SPR, and we also want to reward our existing customers. So here’s the offer:
- Buy 1 mg of any Episentec™ dye reagent – get a free 3-month full version license to our EpiGrammer™ software.
- Buy 2 mg of any Episentec™ dye reagents – get a free 6-month full version license to our EpiGrammer™ software.
- And, as always, we include generous technical support on the implementation of Label-Enhanced SPR to all our customers.
For any enquiries, please contact us at firstname.lastname@example.org.
We have published a new Application Note 025 on the simple and efficient correction of solvent effects in SPR. Label-Enhanced SPR is immune to bulk refractive index variations, so even very large variations in sample solvent composition can be tolerated.
This is especially beneficial when analysing small molecules or fragments in solutions with varying DMSO content. However, the same technique can be used to treat bulk disturbances in general, e.g., the occurrence of varying glycerol concentrations in antibody preparations.
For a copy of the new Application Note 025, or for any other enquiries, please contact us at email@example.com.
Episentec, the company that developed the pioneering Label-Enhanced SPR technology, is now evolving into Episentum. We do this change to highlight the extension of our product range.
Episentum still offers the same high-performance Episentec™ reagents and EpiGrammer™ software for Label-Enhanced SPR, and the same high level of technical support on the implementation of the technology.
We will continue developing and offering products that improve the performance of biosensor instruments, and we’re looking forward to continue serving our customers – old as well as new. For any enquiries, please contact us at firstname.lastname@example.org.
Through our collaboration with Biosensor Applications AB, a leader in the development of mobile equipment for drugs and explosives detection, we are now able to offer highly specific, monoclonal antibodies against drugs of abuse. All antibodies are extensively purified using state-of-the art methodology, carefully quality controlled, and functionally characterized using QCM (quartz crystal microbalance) and SAW (surface acoustic wave) biosensors. Recommended applications are biosensors, optical as well as gravimetric, ELISA, and similar applications requiring high quality, primary antibodies.
Please check out our Monoclonal Antibodies page for more info. For any enquiries and orders regarding antibodies, please contact us at: email@example.com.
To celebrate the approaching end of year 2015, we are offering the following discounts on any orders on our range of Label-Enhanced SPR products placed before the end of the year:
- 15% discount off the list price on all Episentec™ dye reagents.
- 25% discount off the list price on the first annual EpiGrammer™ license.
- Free support on experimental planning and data evaluation for three months for new customers.
For any additional information, for a quotation, or to place an order, please contact firstname.lastname@example.org.
Download pdf here: Episentec December 2015
We have published four new Technical Notes, i.e. simple guides on the practical implementation of Label-Enhanced SPR. Please check out our Technical Notes page for a complete list of available TechNotes, and please contact email@example.com for a copy of any of the TechNotes.
The new TechNotes are:
Technical Note 007: A Biacore™ MDL method template for inhibition-in-solution (ISA) assays
Technical Note 008: A Biacore™ MDL method template for kinetic assays
These two TechNotes contain ready-to-use methods for customers running MDL methods on e.g. Biacore™ 2000 and Biacore™ 3000. The templates can be used right off, or modified according to the user’s requirements.
Technical Note 009: EpiGrammer™ Tutorial 1: Basic case
Technical Note 010: EpiGrammer™ Tutorial 2: Dual-colour case (two binding species)
These two TechNotes contain simple step-by-step instructions on the use of EpiGrammer™ software. TechNote 009 covers the most basic case, while TechNote 010 covers the case with two simultaneously binding species described in our Application Note 024.
Surface Plasmon Resonance is usually regarded as an indiscriminate biosensing technique that monitors the binding of any molecule to the sensor surface, without being able to determine the identity of the binding species. However, using Label-Enhanced SPR, it is possible to discriminate and quantify the binding of two species – one dye-labelled and one unlabelled – simultaneously, even on standard single-wavelength SPR instruments. This feature is very valuable, for example, when studying complex biochemical binding mechanisms, such as competing reactions or allosteric effects. In our new Application Note 024 we present an example on a Biacore™ SPR instrument: the resolution of a mixed, two-species sensorgram into two separate sensorgrams for the two components.
For a copy of the new Application Note 024, or for any other enquiries, please contact firstname.lastname@example.org .