EpiGrammer 3.0 now released

The new improved version 3.0 of our EpiGrammer™ software for sensorgram enhancement is now available off the shelf.

Two separate, individually optimized sensorgram enhancement algorithms have been implemented for the two different generations of Biacore™ instruments: Classic/2000/3000 and T100/T200, respectively. The two generations have slightly different optical systems, and the two algorithms ensure optimum performance for both systems.

The EpiGrammer™ 3.0 Product Data Sheet is available for free download here.

We’re offering a 20% discount on EpiGrammer 3.0 throughout October 2018.

 

New EpiGrammer version: make your best Biacore™ even better

We have launched a new version of the EpiGrammer™ software that improves the performance even of top notch SPR instruments. Contact us on sales@episentum.com for a copy of our latest Application Note 26 to learn how the new version improves the signal-to-noise ratio and reduces the disturbance level of the Biacore™ T200 SPR instrument.

The new EpiGrammer 3.0 version uses improved algorithms for enhanced performance of Biacore™ T100/T200 systems. We are offering a limited number of free trial licenses to the pilot version of EpiGrammer 3.0 to selected customers. If you’re interested, please contact us on sales@episentum.com.

 

New product launch: LE-SPR Validation Kit

We are now offering a Label-Enhanced SPR Validation Kit B9003 to be used as a learning tool or test tool for Biacore™ users that want to get a first acquaintance to the LE-SPR technology. The Validation Kit can also be used to test a SPR instrument, or as a positive control sample during regular LE-SPR analysis. More information on the Validation Kit is found in our recently published Episentum Technical Note 012.

To get a free copy of our Technical Note 012 or for any other enquiries, please contact us at sales@episentum.com.

 

New LE-SPR publication

Label-Enhanced SPR (LE-SPR) can be used to clearly confirm binding site specificity. Brandon Garcia and Brian Geisbrecht at Kansas State University and their co-workers have used LE-SPR in a very elegant manner to study small-molecule inhibitors of the complement system using a standard Biacore™ T200 instrument. Taking advantage of the greatly simplified interpretation of LE-SPR data, binding site specificity was unambiguously confirmed in a way that would have been hard to achieve with conventional SPR.

The full study is recently published in The Journal of Immunology.

For more information about the LE-SPR technology, please contact us directly at info@episentum.com.

 

Episentum presents at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017

Episentum will present a poster at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017. The poster will demonstrate how Label-Enhanced SPR can improve the surface plasmon resonance analysis of small molecules as well as larger biomolecules.

We’re looking forward to meeting with lots of SPR users, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at info@episentum.com.

 

End-of-year offer: Free Label-Enhanced SPR software

To celebrate the approaching Holiday Season, we’re offering free licenses to our Label-Enhanced SPR software. We want to help more scientists get started with LE-SPR, and we also want to reward our existing customers. So here’s the offer:

  • Buy 1 mg of any Episentec™ dye reagent – get a free 3-month full version license to our EpiGrammer™ software.
  • Buy 2 mg of any Episentec™ dye reagents – get a free 6-month full version license to our EpiGrammer™ software.
  • And, as always, we include generous technical support on the implementation of Label-Enhanced SPR to all our customers.

For any enquiries, please contact us at sales@episentum.com.

 

End-of-year offer: Get started with Label-Enhanced SPR

To celebrate the approaching end of year 2015, we are offering the following discounts on any orders on our range of Label-Enhanced SPR products placed before the end of the year:

  • 15% discount off the list price on all Episentec™ dye reagents.
  • 25% discount off the list price on the first annual EpiGrammer™ license.
  • Free support on experimental planning and data evaluation for three months for new customers.

For any additional information, for a quotation, or to place an order, please contact sales@episentum.com.

Download pdf here:   Episentec December 2015

 

New Technical Notes published

We have published four new Technical Notes, i.e. simple guides on the practical implementation of Label-Enhanced SPR. Please check out our Technical Notes page for a complete list of available TechNotes, and please contact sales@episentum.com for a copy of any of the TechNotes.

The new TechNotes are:

Technical Note 007: A Biacore™ MDL method template for inhibition-in-solution (ISA) assays

Technical Note 008: A Biacore™ MDL method template for kinetic assays

These two TechNotes contain ready-to-use methods for customers running MDL methods on e.g. Biacore™ 2000 and Biacore™ 3000. The templates can be used right off, or modified according to the user’s requirements.

Technical Note 009: EpiGrammer™ Tutorial 1: Basic case

Technical Note 010: EpiGrammer™ Tutorial 2: Dual-colour case (two binding species)

These two TechNotes contain simple step-by-step instructions on the use of EpiGrammer™ software. TechNote 009 covers the most basic case, while TechNote 010 covers the case with two simultaneously binding species described in our Application Note 024.

 

Dual-colour SPR on a standard Biacore™ instrument

Surface Plasmon Resonance is usually regarded as an indiscriminate biosensing technique that monitors the binding of any molecule to the sensor surface, without being able to determine the identity of the binding species. However, using Label-Enhanced SPR, it is possible to discriminate and quantify the binding of two species – one dye-labelled and one unlabelled – simultaneously, even on standard single-wavelength SPR instruments. This feature is very valuable, for example, when studying complex biochemical binding mechanisms, such as competing reactions or allosteric effects. In our new Application Note 024 we present an example on a Biacore™ SPR instrument: the resolution of a mixed, two-species sensorgram into two separate sensorgrams for the two components.

For a copy of the new Application Note 024, or for any other enquiries, please contact sales@episentum.com .