Free LE-SPR method files for Biacore S200

We have now adopted the Label-Enhanced SPR technology also to the Biacore™ S200 top-of-the-line SPR instrument. We are now supplying ready-to-use LE-SPR method files for the majority of the Biacore range of instruments: S200, T200, T100, 3000, and 2000.

The ready-to-use method files make it easy to get started with LE-SPR. And even better: the method files are supplied for free to our LE-SPR customers.

We are also interested in developing new method files or templates together with our customers. If you have any enquiries about LE-SPR method development, or if you would want more information about LE-SPR in general, please contact Episentum on


EpiGrammer 3.1 now available

Our EpiGrammer™ software for Label-Enhanced SPR has now been updated to version 3.1. News include:

  • Enhanced performance Increased dynamic range for Biacore™ T100/T200 instruments.
  • Streamlined workflow One-click integration with TraceDrawer™ software for downstream data evaluation: kinetics, affinity, and more. Text format export to Biacore BIAevaluation and other third-party software.

Present users will have the update for free. If you are not a present user, but would be interested in a trial version, please contact us at .

A free download of the product brochure is available here: Product Data Sheets


Check your SPR injections: discount offer

We are happy to offer our Validation Kit B9003 in packs of three for the price of two: €180 in Europe and $220 elsewhere (+ freight). We also include a 1-month free trial license to our EpiGrammer™ software in the package. The offer is valid throughout February 2018.

Accurate Surface Plasmon Resonance analysis requires high quality sample injection pulses. Most commercial SPR instruments offer pre-programmed “System Check” procedures that diagnose injection pulse quality in order to detect e.g. leakage, blockage, or dispersion in the microfluidic system. However, such tests are based on pure refractive index measurements, and are plagued by a number of well-known errors and artefacts.

LE-SPR offers a rigorous injection test that monitors the true transport of analyte in to and out of the detection flow cell without any refractive index artefacts. Using our LE-SPR Validation Kit, the true shape of injection pulses can be accurately assessed by simple inspection.

Learn how by checking out our Technical Note 012. Please contact us at for a copy of the TechNote.


Episentum presents at K4DD meeting, Berlin, October 16-18 2017

Episentum will present a poster at the K4DD meeting “Binding kinetics: Time is of the essence” in Berlin, October 16-18 2017. K4DD is an Innovative Medicines Initiative (IMI) program on Kinetics in Drug Discovery. The title of our poster is “Kinetic Analysis of Small-Molecule Binding with Label-Enhanced SPR”.

Looking forward to getting and update on binding kinetics, and to presenting the potential of LE-SPR in this area. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at


Presentation at Drug Discovery 2017 Meeting, Liverpool, UK, October 3-4 2017

Episentum will give an oral presentation and exhibit a poster at the Drug Discovery 2017 Meeting, Liverpool, UK, 3-4 October 2017. The title of both contributions is “Label-Enhanced SPR for Improved Surface Plasmon Resonance Analysis of Small Molecules and Biomolecules”.

Looking forward to meeting you in Liverpool! For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at


New product launch: LE-SPR Validation Kit

We are now offering a Label-Enhanced SPR Validation Kit B9003 to be used as a learning tool or test tool for Biacore™ users that want to get a first acquaintance to the LE-SPR technology. The Validation Kit can also be used to test a SPR instrument, or as a positive control sample during regular LE-SPR analysis. More information on the Validation Kit is found in our recently published Episentum Technical Note 012.

To get a free copy of our Technical Note 012 or for any other enquiries, please contact us at