Free LE-SPR method files for Biacore S200

We have now adopted the Label-Enhanced SPR technology also to the Biacore™ S200 top-of-the-line SPR instrument. We are now supplying ready-to-use LE-SPR method files for the majority of the Biacore range of instruments: S200, T200, T100, 3000, and 2000.

The ready-to-use method files make it easy to get started with LE-SPR. And even better: the method files are supplied for free to our LE-SPR customers.

We are also interested in developing new method files or templates together with our customers. If you have any enquiries about LE-SPR method development, or if you would want more information about LE-SPR in general, please contact Episentum on


Run ELISA on your SPR instrument!

Episentum is developing a high-sensitivity, ELISA-like sandwich assay format for Biacore SPR instruments. The format is based on the proprietary Label-Enhanced SPR technology of Episentum, and will utilize standard commercial ELISA kits.

The new format can be used to replace plate-based ELISA assays with real-time Biacore assays. Or, the other way around: to develop new ELISA kits and methodology using Biacore as a development tool.

We are now looking for development partners for the further refinement and testing of the new assay format. If you’re interested – for example if you are an ELISA developer, an ELISA end user, or if you’re interested in transferring ELISA assays to the Biacore – please call back at for more details.


EpiGrammer 3.1 now available

Our EpiGrammer™ software for Label-Enhanced SPR has now been updated to version 3.1. News include:

  • Enhanced performance Increased dynamic range for Biacore™ T100/T200 instruments.
  • Streamlined workflow One-click integration with TraceDrawer™ software for downstream data evaluation: kinetics, affinity, and more. Text format export to Biacore BIAevaluation and other third-party software.

Present users will have the update for free. If you are not a present user, but would be interested in a trial version, please contact us at .

A free download of the product brochure is available here: Product Data Sheets


New EpiGrammer version: make your best Biacore™ even better

We have launched a new version of the EpiGrammer™ software that improves the performance even of top notch SPR instruments. Contact us on for a copy of our latest Application Note 26 to learn how the new version improves the signal-to-noise ratio and reduces the disturbance level of the Biacore™ T200 SPR instrument.

The new EpiGrammer 3.0 version uses improved algorithms for enhanced performance of Biacore™ T100/T200 systems. We are offering a limited number of free trial licenses to the pilot version of EpiGrammer 3.0 to selected customers. If you’re interested, please contact us on


New product launch: LE-SPR Validation Kit

We are now offering a Label-Enhanced SPR Validation Kit B9003 to be used as a learning tool or test tool for Biacore™ users that want to get a first acquaintance to the LE-SPR technology. The Validation Kit can also be used to test a SPR instrument, or as a positive control sample during regular LE-SPR analysis. More information on the Validation Kit is found in our recently published Episentum Technical Note 012.

To get a free copy of our Technical Note 012 or for any other enquiries, please contact us at


New LE-SPR publication

Label-Enhanced SPR (LE-SPR) can be used to clearly confirm binding site specificity. Brandon Garcia and Brian Geisbrecht at Kansas State University and their co-workers have used LE-SPR in a very elegant manner to study small-molecule inhibitors of the complement system using a standard Biacore™ T200 instrument. Taking advantage of the greatly simplified interpretation of LE-SPR data, binding site specificity was unambiguously confirmed in a way that would have been hard to achieve with conventional SPR.

The full study is recently published in The Journal of Immunology.

For more information about the LE-SPR technology, please contact us directly at


Episentum presents at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017

Episentum will present a poster at the Advances in Drug Discovery meeting, Cambridge, UK, 6-7 March 2017. The poster will demonstrate how Label-Enhanced SPR can improve the surface plasmon resonance analysis of small molecules as well as larger biomolecules.

We’re looking forward to meeting with lots of SPR users, including old and new customers. For any information on LE-SPR prior to the meeting, or to book a one-to-one meeting, please contact us at


End-of-year offer: Free Label-Enhanced SPR software

To celebrate the approaching Holiday Season, we’re offering free licenses to our Label-Enhanced SPR software. We want to help more scientists get started with LE-SPR, and we also want to reward our existing customers. So here’s the offer:

  • Buy 1 mg of any Episentec™ dye reagent – get a free 3-month full version license to our EpiGrammer™ software.
  • Buy 2 mg of any Episentec™ dye reagents – get a free 6-month full version license to our EpiGrammer™ software.
  • And, as always, we include generous technical support on the implementation of Label-Enhanced SPR to all our customers.

For any enquiries, please contact us at


End-of-year offer: Get started with Label-Enhanced SPR

To celebrate the approaching end of year 2015, we are offering the following discounts on any orders on our range of Label-Enhanced SPR products placed before the end of the year:

  • 15% discount off the list price on all Episentec™ dye reagents.
  • 25% discount off the list price on the first annual EpiGrammer™ license.
  • Free support on experimental planning and data evaluation for three months for new customers.

For any additional information, for a quotation, or to place an order, please contact

Download pdf here:   Episentec December 2015