Please check out our new web page listing scientific publications relating to Label-Enhanced SPR and some SPR publications of general background interest!
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Tag Archives: biosensor
New LE-SPR publication
Label-Enhanced SPR (LE-SPR) can be used to clearly confirm binding site specificity. Brandon Garcia and Brian Geisbrecht at Kansas State University and their co-workers have used LE-SPR in a very elegant manner to study small-molecule inhibitors of the complement system using a standard Biacore™ T200 instrument. Taking advantage of the greatly simplified interpretation of LE-SPR data, binding site specificity was unambiguously confirmed in a way that would have been hard to achieve with conventional SPR.
The full study is recently published in The Journal of Immunology.
For more information about the LE-SPR technology, please contact us directly at info@episentum.com.
End-of-year offer: Free Label-Enhanced SPR software
To celebrate the approaching Holiday Season, we’re offering free licenses to our Label-Enhanced SPR software. We want to help more scientists get started with LE-SPR, and we also want to reward our existing customers. So here’s the offer:
- Buy 1 mg of any Episentec™ dye reagent – get a free 3-month full version license to our EpiGrammer™ software.
- Buy 2 mg of any Episentec™ dye reagents – get a free 6-month full version license to our EpiGrammer™ software.
- And, as always, we include generous technical support on the implementation of Label-Enhanced SPR to all our customers.
For any enquiries, please contact us at sales@episentum.com.
New Products: Monoclonal Antibodies
Through our collaboration with Biosensor Applications AB, a leader in the development of mobile equipment for drugs and explosives detection, we are now able to offer highly specific, monoclonal antibodies against drugs of abuse. All antibodies are extensively purified using state-of-the art methodology, carefully quality controlled, and functionally characterized using QCM (quartz crystal microbalance) and SAW (surface acoustic wave) biosensors. Recommended applications are biosensors, optical as well as gravimetric, ELISA, and similar applications requiring high quality, primary antibodies.
Please check out our Monoclonal Antibodies page for more info. For any enquiries and orders regarding antibodies, please contact us at: sales@episentum.com.
End-of-year offer: Get started with Label-Enhanced SPR
To celebrate the approaching end of year 2015, we are offering the following discounts on any orders on our range of Label-Enhanced SPR products placed before the end of the year:
- 15% discount off the list price on all Episentec™ dye reagents.
- 25% discount off the list price on the first annual EpiGrammer™ license.
- Free support on experimental planning and data evaluation for three months for new customers.
For any additional information, for a quotation, or to place an order, please contact sales@episentum.com.
Download pdf here: Episentec December 2015
New Technical Notes published
We have published four new Technical Notes, i.e. simple guides on the practical implementation of Label-Enhanced SPR. Please check out our Technical Notes page for a complete list of available TechNotes, and please contact sales@episentum.com for a copy of any of the TechNotes.
The new TechNotes are:
Technical Note 007: A Biacore™ MDL method template for inhibition-in-solution (ISA) assays
Technical Note 008: A Biacore™ MDL method template for kinetic assays
These two TechNotes contain ready-to-use methods for customers running MDL methods on e.g. Biacore™ 2000 and Biacore™ 3000. The templates can be used right off, or modified according to the user’s requirements.
Technical Note 009: EpiGrammer™ Tutorial 1: Basic case
Technical Note 010: EpiGrammer™ Tutorial 2: Dual-colour case (two binding species)
These two TechNotes contain simple step-by-step instructions on the use of EpiGrammer™ software. TechNote 009 covers the most basic case, while TechNote 010 covers the case with two simultaneously binding species described in our Application Note 024.
LE-SPR at Biacore User Meeting, Berlin, October 1st-2nd
We will complete our European Biacore™ User Meeting roundtrip by presenting the Label-Enhanced SPR concept at the Biacore User Meeting in Berlin, Germany, 1-2 October 2015. Looking forward to networking with many Biacore users and to discussing Label-Enhanced SPR applied to small molecules as well as proteins. For any information prior to the meeting, please contact us at sales@episentum.com.
LE-SPR at Biacore User Meeting, Stansted Airport, UK
Episentec will present the Label-Enhanced SPR concept at the Biacore™ User Meeting at Stansted Airport, UK, 23-24 September 2015. Looking forward to meeting many British Biacore users and to discussing Label-Enhanced SPR applied to small molecules as well as proteins. For any information prior to the meeting, please contact us at sales@episentum.com.
Meet Episentec at the Drug Discovery ’15 meeting in Telford, UK, 2-3 September 2015
Take the opportunity to meet with Episentec at the ELRIG Drug Discovery ’15 conference in Telford, UK, 2-3 September 2015. We will present a poster showing how Label-Enhanced SPR improves both the detectability and the specificity in Surface Plasmon Resonance analysis of antibodies and proteins as well as small molecules and fragments.
We will also spend a few days extra in the UK, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Telford, please contact us and we’ll arrange a meeting!
Please contact us at sales@episentum.com for any enquiries.
New Application Note 023 on antibody analysis
Label-Enhanced SPR is already a well-established tool that improves the detectability of small molecules in SPR analysis 100-fold. Our new Application Note 23 shows how also the detectability of antibodies can be improved 100-fold. The key feature here is not the enhanced sensitivity but the enhanced specificity, or in other words, the elimination of signal contributions from non-specific binding of undefined sample substances.
Please check out our Application Notes page for more info or order the new document directly from sales@episentum.com.