The Biophysics group at Genentech has published a new paper on the use of ‘chaser’ assays to study extremely long dissociation times, which has been added to our Scientific Publications page. The corresponding poster was honoured with the poster award at the recent GE Healthcare DiPIA 2018 conference in Boston.
Label-Enhanced SPR (LE-SPR) can be used to clearly confirm binding site specificity. Brandon Garcia and Brian Geisbrecht at Kansas State University and their co-workers have used LE-SPR in a very elegant manner to study small-molecule inhibitors of the complement system using a standard Biacore™ T200 instrument. Taking advantage of the greatly simplified interpretation of LE-SPR data, binding site specificity was unambiguously confirmed in a way that would have been hard to achieve with conventional SPR.
The full study is recently published in The Journal of Immunology.
For more information about the LE-SPR technology, please contact us directly at info@episentum.com.