Tag Archives: spr

Meet Episentec at the Drug Discovery ’15 meeting in Telford, UK, 2-3 September 2015

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Take the opportunity to meet with Episentec at the ELRIG Drug Discovery ’15 conference in Telford, UK, 2-3 September 2015. We will present a poster showing how Label-Enhanced SPR improves both the detectability and the specificity in Surface Plasmon Resonance analysis of antibodies and proteins as well as small molecules and fragments.

We will also spend a few days extra in the UK, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Telford, please contact us and we’ll arrange a meeting!

Please contact us at sales@episentum.com for any enquiries.

Meet Episentec in Gent, Belgium, 15-16 June 2015 at “Next-Generation Antibodies and Protein Analysis: Tools & Technologies”

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Take the opportunity to meet with Episentec at the “Next-Generation Antibodies and Protein Analysis: Tools & Technologies” conference in Gent, Belgium, 15-16 June 2015. We will present a poster showing how Label-Enhanced SPR improves the detectability and widens the dynamic range in protein and antibody analysis using Biacore™ instruments.

We will also spend 17 June in the Gent area, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Gent, please contact us and we’ll arrange a meeting!

Please contact us at sales@episentum.com for any enquiries.

New Application Note 023 on antibody analysis

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Label-Enhanced SPR is already a well-established tool that improves the detectability of small molecules in SPR analysis 100-fold. Our new Application Note 23 shows how also the detectability of antibodies can be improved 100-fold. The key feature here is not the enhanced sensitivity but the enhanced specificity, or in other words, the elimination of signal contributions from non-specific binding of undefined sample substances.

Please check out our Application Notes page for more info or order the new document directly from sales@episentum.com.

New EpiGrammer version – Free trial license

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We have developed a new, improved version of the EpiGrammer™ software for Label-Enhanced SPR, and celebrate this with a special offer:

A free 3-month EpiGrammer trial license to all new Episentec™ dye reagent customers in April 2015.

EpiGrammer software is used for calculating enhanced sensorgrams based on our proprietary Label-Enhanced SPR technology:

  • 100-fold improved sensitivity as compared to standard SPR sensorgrams.
  • 100% specificity with respect to the dye-labelled species.

News in version 2.1:

  • Extended linear dynamic range and more efficient rejection of large disturbances.
  • Improved quantification of small binding levels in presence of varying DMSO concentrations.
  • The interactive, easy-to-use graphical interface and the data import/export routines are unchanged.

Please contact sales@episentum.com for any enquiries or to place an order.

Episentec to present at the MRC Laboratory of Molecular Biology, Cambridge, UK

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The CEO of Episentec, Anders Hanning, has been invited to give a presentation about Label-Enhanced SPR at the MRC Laboratory of Molecular Biology (LMB), Cambridge, UK. The LMB, sometimes nicknamed ‘The Nobel Prize Factory’, has received 10 Nobel prizes shared amongst 14 individuals, including names such as Watson & Crick (DNA structure), Milstein & Köhler (monoclonal antibodies), and Sanger (protein sequencing & DNA sequencing). The presentation will cover applications of Label-Enhanced SPR in the analysis of proteins, nucleic acids, and small molecules.

Meet Episentec at Fragments 2015 in Cambridge, UK, 22-24 March 2015

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We will participate and present a poster on Label-Enhanced SPR at the 5th RSC-BMCS Fragment-based Drug Discovery Meeting in Cambridge, UK, 22-24 March 2015.

We will also spend 25-26 March in the Cambridge area, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Cambridge, please contact us and we’ll arrange a meeting!

Please contact us at info@episentum.com for any enquiries.

New Application Note 022 on protein analysis

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Label-Enhanced SPR has already been well established as a powerful tool to improve small molecule analysis on SPR instruments, but now the Label-Enhanced SPR concept has been successfully extended also to improved protein analysis. Details are found in our new Application Note 022 on protein analysis.

Please check out our Application Notes page for more info or order the new document directly from sales@episentum.com.

New Application Note 021 on fragment kinetics

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Our new Application Note 021 demonstrates how label-enhanced SPR expands the measurable kinetic space for fragments and small molecules into previously intractable regions. This provides new unique insights into lead optimization of small molecules and a novel understanding of how the dynamics of interactions involving weakly binding and/or low molecular weight compounds relate to protein function.

Please check out our Application Notes page for more info or order the new document directly from sales@episentec.com.