Tag Archives: biacore

New Technical Notes published

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We have published four new Technical Notes, i.e. simple guides on the practical implementation of Label-Enhanced SPR. Please check out our Technical Notes page for a complete list of available TechNotes, and please contact sales@episentum.com for a copy of any of the TechNotes.

The new TechNotes are:

Technical Note 007: A Biacore™ MDL method template for inhibition-in-solution (ISA) assays

Technical Note 008: A Biacore™ MDL method template for kinetic assays

These two TechNotes contain ready-to-use methods for customers running MDL methods on e.g. Biacore™ 2000 and Biacore™ 3000. The templates can be used right off, or modified according to the user’s requirements.

Technical Note 009: EpiGrammer™ Tutorial 1: Basic case

Technical Note 010: EpiGrammer™ Tutorial 2: Dual-colour case (two binding species)

These two TechNotes contain simple step-by-step instructions on the use of EpiGrammer™ software. TechNote 009 covers the most basic case, while TechNote 010 covers the case with two simultaneously binding species described in our Application Note 024.

 

Dual-colour SPR on a standard Biacore™ instrument

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Surface Plasmon Resonance is usually regarded as an indiscriminate biosensing technique that monitors the binding of any molecule to the sensor surface, without being able to determine the identity of the binding species. However, using Label-Enhanced SPR, it is possible to discriminate and quantify the binding of two species – one dye-labelled and one unlabelled – simultaneously, even on standard single-wavelength SPR instruments. This feature is very valuable, for example, when studying complex biochemical binding mechanisms, such as competing reactions or allosteric effects. In our new Application Note 024 we present an example on a Biacore™ SPR instrument: the resolution of a mixed, two-species sensorgram into two separate sensorgrams for the two components.

For a copy of the new Application Note 024, or for any other enquiries, please contact sales@episentum.com .

 

September offer: Large discounts on Label-Enhanced SPR products

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To help you get a head start in the lab after the summer break, we offer substantial discounts on all orders placed in September 2015:

  • 15% discount on all Episentec™ dye reagents in the B2 and B3 series for Biacore™.
  • 25% discount on our EpiGrammer™ 2.1 software for all new dye customers.

Remember, Label-Enhanced SPR can help you boost the performance of your Surface Plasmon Resonance instrument:

  • 100-fold improved sensitivity – as compared to standard sensorgrams.
  • 100% specificity – with respect to the labelled species.

Please contact sales@episentum.com for any enquiries or to place an order, and claim our September discounts.

Dowload pdf here: Episentec September campaign

 

Meet Episentec at the Drug Discovery ’15 meeting in Telford, UK, 2-3 September 2015

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Take the opportunity to meet with Episentec at the ELRIG Drug Discovery ’15 conference in Telford, UK, 2-3 September 2015. We will present a poster showing how Label-Enhanced SPR improves both the detectability and the specificity in Surface Plasmon Resonance analysis of antibodies and proteins as well as small molecules and fragments.

We will also spend a few days extra in the UK, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Telford, please contact us and we’ll arrange a meeting!

Please contact us at sales@episentum.com for any enquiries.

Meet Episentec in Gent, Belgium, 15-16 June 2015 at “Next-Generation Antibodies and Protein Analysis: Tools & Technologies”

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Take the opportunity to meet with Episentec at the “Next-Generation Antibodies and Protein Analysis: Tools & Technologies” conference in Gent, Belgium, 15-16 June 2015. We will present a poster showing how Label-Enhanced SPR improves the detectability and widens the dynamic range in protein and antibody analysis using Biacore™ instruments.

We will also spend 17 June in the Gent area, so if you’re interested in Label-Enhanced SPR and if you’re site is not too far from Gent, please contact us and we’ll arrange a meeting!

Please contact us at sales@episentum.com for any enquiries.

New Application Note 023 on antibody analysis

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Label-Enhanced SPR is already a well-established tool that improves the detectability of small molecules in SPR analysis 100-fold. Our new Application Note 23 shows how also the detectability of antibodies can be improved 100-fold. The key feature here is not the enhanced sensitivity but the enhanced specificity, or in other words, the elimination of signal contributions from non-specific binding of undefined sample substances.

Please check out our Application Notes page for more info or order the new document directly from sales@episentum.com.

New Application Note 022 on protein analysis

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Label-Enhanced SPR has already been well established as a powerful tool to improve small molecule analysis on SPR instruments, but now the Label-Enhanced SPR concept has been successfully extended also to improved protein analysis. Details are found in our new Application Note 022 on protein analysis.

Please check out our Application Notes page for more info or order the new document directly from sales@episentum.com.